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Brukinsa 80mg Capsule

℞
Prescription Required
Store the medicine at room temperature (20 - 25°C), away from moisture and heat.
MRP₹2,79,375.0012% OFF
₹2,45,850.00

Inclusive of all taxes

Packaging:Bottle of 120 Capsules
Brukinsa 80mg Capsule

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Protective climate-sealed dispatch across India within 4 to 24 hours.

Licensed Network
Store at room temperature (20 - 25°C)
Rx Verification
Express Dispatch

Financial Assistance Available

Contact our oncology support team to check your eligibility for manufacturer patient assistance programs (PAP) for Brukinsa 80mg Capsule.

About this medicine

Brukinsa 80mg Capsule (ZANUBRUTINIB)is a prescription oncology medicine. Below is educational product information — follow your doctor's advice for dose and use.

Brukinsa 80mg Capsule is a prescription antineoplastic medication containing zanubrutinib, a targeted small-molecule inhibitor of Bruton's tyrosine kinase (BTK). It is indicated for the treatment of specific hematologic malignancies, particularly in adult patients who have received at least one prior systemic therapy. By selectively binding to and inhibiting the BTK protein, zanubrutinib disrupts the B-cell receptor signaling pathway, preventing the proliferation and survival of malignant B cells. Administered orally in capsule form, treatment with This medicine must be initiated and managed under the supervision of a qualified oncologist. This medication requires careful clinical evaluation prior to and during therapy; baseline blood work, including complete blood counts and liver function assessments, must be routinely monitored. Special caution is required for patients with pre-existing hepatic impairment, cardiac arrhythmias, or severe hypertension. Brukinsa is strictly contraindicated during pregnancy and breastfeeding due to the risk of fetal harm and adverse effects on nursing infants. Women of childbearing potential and male patients with female partners of reproductive potential must utilize effective contraception during treatment and for the recommended duration following the final dose.

Quick Facts

Molecule nameZanubrutinib
Pharmacological classBruton’s tyrosine kinase (BTK) inhibitor
Therapeutic classAnti-cancer medicine
Indications1. Mantle Cell Lymphoma (MCL) 2. Chronic Lymphocytic Leukaemia (CLL) or Small Lymphocytic Lymphoma (SLL) 3. Waldenström’s Macroglobulinemia (WM) 4. Marginal Zone Lymphoma (MZL) 5. Follicular Lymphoma (FL)

Composition / Active Salt

ZANUBRUTINIB

Dosage Form

Capsule

Prescription Status

Doctor's Rx Required

What if you miss a dose?

If you miss a dose of Brukinsa 80mg Capsule, take it as soon as you remember on the same day. Return to your normal dosing schedule the following day.

Uses of Brukinsa 80mg Capsule

Mantle Cell Lymphoma (MCL) – in adults who’ve had at least one previous treatment
Chronic Lymphocytic Leukaemia (CLL) or Small Lymphocytic Lymphoma (SLL)
Waldenström’s Macroglobulinemia (WM)
Marginal Zone Lymphoma (MZL) – after treatment with an anti-CD20 medicine
Follicular Lymphoma (FL) – limited use or under review in some places

Side Effects of Brukinsa 80mg Capsule

Oncology medicines should be administered strictly under medical supervision. Inform your oncologist immediately if you experience adverse symptoms.

Diarrhea
Muscle pain
Cough
Rash
Low white blood cell count
Tiredness
Bruising easily
Serious infections (fever, chills, shortness of breath)
Bleeding or blood in stool/urine
Irregular heartbeat or chest pain
Liver problems (yellowing of skin or eyes)
Severe allergic reactions (swelling, rash, difficulty breathing)

Clinical Safety Advice for Brukinsa 80mg Capsule

Follow expert clinical guidelines regarding interactions, precautions, and medical conditions when taking Brukinsa 80mg Capsule.

Pregnancy
UNSAFE

Pregnancy UNSAFE Brukinsa 80mg Capsule is strictly unsafe during pregnancy as it can cause fetal harm and embryo-fetal toxicity. Inform your oncologist immediately if you are pregnant, suspect you may be pregnant, or plan to become pregnant. Females of reproductive potential must use highly effective contraception during treatment and continue for at least 1 week after the final dose. Male patients with female partners of reproductive potential must also use effective contraception during therapy and for at least 1 week post-treatment.

Breast Feeding
UNSAFE

Breastfeeding is not recommended during treatment with Brukinsa 80mg Capsule. It is unknown whether zanubrutinib passes into human breast milk, but due to the potential for serious adverse reactions in nursing infants, patients should avoid breastfeeding during treatment and for at least 2 weeks following the last dose.

Liver
CONSULT YOUR DOCTOR

Brukinsa 80mg Capsule is extensively metabolized in the liver. Patients with severe hepatic impairment (Child-Pugh Class C) require a reduced dose (80mg twice daily) and close clinical monitoring. Baseline liver function tests should be conducted prior to initiating therapy and monitored regularly throughout treatment.

Alcohol
UNSAFE

Alcohol consumption should be avoided or strictly minimized during treatment with Brukinsa 80mg Capsule. Concurrent alcohol use may exacerbate central nervous system side effects like dizziness and fatigue, increase the risk of liver toxicity, and worsen gastrointestinal irritation.

Driving
CONSULT YOUR DOCTOR

Brukinsa 80mg Capsule may cause fatigue, dizziness, and asthenia in some patients. Refrain from driving, operating machinery, or engaging in tasks requiring complete mental concentration until you have established how the medication affects your cognitive and physical abilities.

Storage & Delivery Protocol

Preservation and climate-safe dispatch guidelines for Brukinsa 80mg Capsule across India.

Store at room temperature (20 - 25°C)

Storage Conditions

Store at room temperature between 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C. Keep capsules in their original container, protected from moisture and direct heat. Keep out of reach of children. Dispose of unused medication following hazardous drug handling standards.

Climate-Sealed Transit

Dispatched in protective, tamper-evident and moisture-sealed packaging.

Rx Verification

Prescription and genuine batch validated prior to dispatch.

Frequently Asked Questions

Brukinsa 80mg Capsule is a targeted antineoplastic medication indicated for the treatment of specific B-cell malignancies, including mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), marginal zone lymphoma (MZL), Waldenström’s macroglobulinemia (WM), and follicular lymphoma (FL). It works by inhibiting Bruton's tyrosine kinase (BTK), thereby disrupting signal transduction pathways essential for malignant cell proliferation and survival.

Yes, Brukinsa 80mg Capsule is effective in managing advanced-stage B-cell malignancies, including stage IV MCL, CLL, and MZL. By continuously blocking BTK-mediated signaling, it helps reduce tumor burden, achieve durable disease responses, and delay progression, even in patients with relapsed or refractory disease.

Yes, Brukinsa 80mg Capsule can be administered with or without food. However, it should be swallowed whole at approximately the same times each day to ensure stable therapeutic drug levels.

Treatment duration with Brukinsa 80mg Capsule is determined by your oncologist. It is typically continued as long as clinical benefit is maintained or until disease progression or unacceptable toxicity occurs. Your healthcare provider will conduct regular monitoring to evaluate treatment efficacy and safety.

Patients taking Brukinsa 80mg Capsule should avoid grapefruit, grapefruit juice, and Seville oranges, as they can inhibit CYP3A enzymes and significantly increase drug concentrations in the body. Additionally, inform your oncologist before taking blood thinners (antiplatelets/anticoagulants), strong CYP3A inhibitors or inducers (such as certain antifungals, antibiotics, or St. John’s Wort), and avoid receiving live attenuated vaccines during therapy.

Have questions about your cancer prescription?

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